The pioneer of anticancer drugs: cisplatin
WebbWe summarized the recent 5 years of different research progress on clinical applications and antitumor mechanisms of TCM in the treatment of lung cancer. As a ... [EGFRs] tyrosine kinase inhibitors [TKIs]) effects as well as provide synergistic effects, enhance chemotherapy drugs chemosensitivity, reverse drug resistance, reduce adverse ... WebbAbstract: This review provides a brief view of the cisplatin's mechanism of action, toxicity …
The pioneer of anticancer drugs: cisplatin
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Webb17 jan. 2024 · A simple, sensitive and repeatable D 2 O-single cell Raman spectroscopy method is developed to quantify the inhibitory activity of anticancer drugs on cancer cell metabolism. The IC 50 values obtained from A549 cells incubated with cisplatin and taxol are comparable with results of CCK-8 and ATP luminescent cell viability assays. WebbFollowing its approval as second-line monotherapy for locally advanced or metastatic non-squamous NSCLC, pemetrexed has established itself as the first-line regimen in combination with cisplatin, and its powerful antitumor effects and less cumulative toxicities were then taken advantage of in the JMEN and PARAMOUNT trials, …
Webb3 maj 2024 · Drugs like carboplatin, vinblastine, doxorubicin, melphalan, etc. cause bone marrow depression while adverse effect like aplastic anemia is caused due to administration of drugs such as cisplatin ... Webb1 juli 2024 · Abstract. Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its ...
http://www.dxhx.pku.edu.cn/EN/Y2024/V35/I1/40 Webb12 nov. 2024 · This is a crucial step in the early stages of the drug development pipeline and raises the chances of a drug candidate making it through the clinical assessment phases. For instance, the mode of action of anticancer complexes such as cisplatin and related analogues has been established through thorough mechanistic investigations …
WebbDescription. 30 years after its discovery as an antitumor agent, cisplatin represents today …
WebbDespite the fact that CRS/HIPEC practices are widely variable, 12,42 the majority of HIPEC studies on ovarian cancer have used i.p. cisplatin, 8,12,42,43 which could also be employed in routine clinical practice as a single agent according to most experts. 42 The duration of perfusion with this drug may reach 160 minutes (usually ranging from 30 to 120 … content of academic textWebb7 feb. 2024 · Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, such as lack of selectivity, high systemic toxicity, and drug resistance, seriously limit their clinical application. With advancements in nanotechnology and chemical synthesis, Pt ... efffys closetWebbThe initial pioneering efforts of Clearfield and Alberti are being continued by numerous research groups providing new exciting areas of development on the chemistry of layered M ... We report the use of zirconium phosphate (ZrP) nanoplatelets for the encapsulation of the anticancer drug cisplatin and its delivery to tumor cells. eff fightWebb1 jan. 2024 · Cisplatin was absorbed more readily than carboplatin, both in vitro and in … eff frameworkThe compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University discovered that electrolysis of platinum electrodes generated a soluble platinum complex which inhibited binary fission in Escherichia coli (E. coli) bacteria. Although bacterial cell growth continued, cell division … eff furnitureWebbThe story of the invention of the anticancer drug cisplatin is a story of chemistry hidden … eff feedingWebbThe rediscovery of platinum-based cancer therapy Platinum (Pt) compounds entered the … eff free download